*NEUROMONITORING [IONM] is a common term used to describe an evidence based patient care provided by Neurophysiologists with PhD/ M.D. The most appropriate term used to refer this medical health care field is Intra-Operative Neurophysiological Monitoring(IONM). *For consultancy use the contact/feedback form.
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Saturday, April 10, 2021
Intraoperative NeuroMonitoring, some recent articles of interest!?.
EMG & EEG
Evoked Potentials
"Sensory Processes": Smell, Vision, Taste, Hearing and Touch Receptors and information processing
Brief Reviews on all the sensory processes, a good read!. It is not extensive but for college students and graduate level neuroscience and neurophysiology studies, a good reading material.
Sensory Processes | Boundless Psychology (lumenlearning.com)
The Nose and Nasal Cavity
Olfactory sensitivity is directly proportional to spatial area in the nose—specifically the olfactory epithelium, which is where odorant reception occurs. The area in the nasal cavity near the septum is reserved for the olfactory mucous membrane, where olfactory receptor cells are located. This area is a dime-sized region called the olfactory mucosa. In humans, there are about 10 million olfactory cells, each of which has 350 different receptor types composing the mucous membrane. Each of the 350 receptor types is characteristic of only one odorant type. Each functions using cilia, small hair-like projections that contain olfactory receptor proteins. These proteins carry out the transduction of odorants into electrical signals for neural processing.
Sunday, June 7, 2020
Saturday, December 14, 2019
Special Reviews on Cancer Cell Biology, JCB!
An interesting special reviews edition on Cellular mechanism of Cancer has been published by JCB. This reviews collection provides the most updated research reports and experimental results on cancer that can be of interest to researchers, pharma companies and clinicians."Special Collection of Reviews on Cancer Cell Biology".
We are pleased to present this collection of reviews on the cell biology of cancer. Basic science provides the foundation for progress in cancer biology, and we are delighted to highlight reviews discussing fundamental cell biological discoveries and how these latest advances can be harnessed therapeutically for translational development. Learn about the cellular mechanisms protecting genome stability at sites of stalled DNA replication.
Read about the relationship between signaling and endocytosis in cancer, and how this can enhance cancer cell survival, migration, and proliferation.
Tumor tissues exhibit altered mechanical properties\
Here is: Link and further details.
Wednesday, August 23, 2017
Whole Brain Atlas: This Online Whole Brain Atlas is a Treat for Advanced Clinicians and Researchers
The whole brain atlas created or compiled by two Harvard MDs Keith and Alex is a great collection of various brain areas or for that matter all levels and depths of whole brain.
From Whole Brain Atlas |
The Whole Brain Atlas |
Their work and data is a must visit for advanced Neurophysiologists, Radiologists and all the spine, neck and brain surgeons, besides medical students planning to specialize in Brain and Spine. Here is the Link:Website/Url.
This digital wealth of information of whole brain structure and anatomy is a comprehensive work using various imaging such as MRI, CT and SPECT besides other anatomical tracing techniques put together to reveal the entire brain, along with images there are also videos such as video of the "Circle of Willis" and various vascular structures supplying brain areas, as I traveled through their site, it was like feasting euphorically!.
As you browse through the contents, there is so much to add besides whole brain atlas, the images revealing abnormal brain areas in various neurodegenerative/neurological disease is something clinicians can benefit a lot.
More updates after I review the whole site.....!!
Thursday, December 25, 2014
Comments & Messages: Use Emails Please
Thank you the "anny" for sending a message, please feel free to write to me via email or call me, I will appreciate greatly."**Please Email: Follow the Contact Form on the Right Panel------->
Friday, October 3, 2014
TBI or Sports Brain Injuries-Diagnosis without Opening the Skull?
My Editorial and Review on Recent Trends in Brain Damage is next, in the mean time, this is the latest news about Traumatic Brain Injruy (TBI) and how Spreading Depolarization can be tapped using neuromonitoring and how that can be used to understand and interpret the brain damage without opening the skull, what I meant is without a neurosurgery?.
Saturday, September 13, 2014
LLIF-Lateral Lumbar Interbody Fusion Procedure
Wednesday, July 30, 2014
Epilepsy, what is going on in the Epilepsy Research and is there any Advancement?. Nature Journals Special Issue..
There is also another recent Special issue on Neuroscience published somewhere in late 2013, about which I will write later. This Editorial is to provide some idea to researchers, clinicians and people who are working in the field of Epilepsy that this might be the best issue to update yourself about the field and the recent developments in Epilepsy. Ofcourse, those patients and relatives who can understand the science behind Epilepsy, who are wondering what is really going on and what are the possible treatments available, might be a good place to check.
From Nature's Cover Image Content:
Mike May, the contributing Editor has given a brief summary of the entire issue, a good place to start reading this issue: http://www.nature.com/nature/journal/v511/n7508_supp/full/511S1a.html
Note: This special is issue is only open to public or non subscribers upto October, so better read before it will be taken of the shelf or go get a copy of it.
Interesting research reports presented by the field's top scientists/researchers, clinicians and more. I will go through the entire issue pretty much cover to cover, but before I spend time, I thought to share this for those who may not have heard about this special issue. The first Chapter or section begins with the background information about the basics of Epilepsy the origin of Excitation or Excitement, and there are sections on genetic basis, drug treatment modalities as well as technologies that can detect the types and details of the epilepsy. Other sections regarding the Epidemiology and types of this disease, management and social issues including the misunderstanding and tabo's of epilepsy, sociology of it, and the issue ends with what is food got to do with Epilepsy or what food intake might be the best for people with seizure or epileptic episodes. Overall, seems like a great issue with a comprehensive knowledge about the disease, complexities and its future. I hope I can write a real Editorial with scientific temperament when I am done reading the whole issue.......
Epilepsy is a common neurological condition that affects 50 million people worldwide. For many patients, medication helps reduce seizure frequency; for drug-resistant epilepsy, treatments include diet therapy and neurosurgery. Although discussed and feared for millennia, progress towards understanding epilepsy has been slow — even with help from modern genetic and neurological analysis. Stigmatization of people with epilepsy continues in certain parts of the world and though lack of funding limits epilepsy research, new ways to treat and manage seizures are on the horizon.
Free full access
Cover Art: Nik Spencer
Wednesday, July 23, 2014
Yumen City of China is Sealed off to outside world?, Did China just make a bizzare decision or a informed Right one as a Precaution?.
Plague is treatable disease, diligence and scientific approach is a must but not panicky and seal off of a city. Here is a NIH site with a treatment info:Updates!: One would expect more news or updates on this sealed off city in China, nothing came out after the initial news?...Whatever news came out on this issue was in the month of July?.
Image on the left: This Flea is a carrier of Plague Bacteria.
at the bottom is the image of the bacteria: Yersinia Pestis
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-------------------------------------------------------------------------------------------------PubMed Health: Plague Treatment
People with the plague need immediate treatment. If treatment is not received within 24 hours of when the first symptoms occur, death can result.
Antibiotics such as streptomycin, gentamicin, doxycycline, or ciprofloxacin are used to treat plague. Oxygen, intravenous fluids, and respiratory support usually are also needed.
Patients with pneumonic plague should be strictly isolated from caregivers and other patients. People who have had contact with anyone infected by pneumonic plague should be watched carefully and given antibiotics as a preventive measure.
City of Yumen, China |
What exactly is happening in Yumen City right now:The following news piece is not related to our field of Neuromonitoring but to disease, medicine and general health care. The way this disease and a case of death has been dealt with a country as large as China is bit unusual and rather bizarre, why?.
MSN News: The 30,000 people living in Yumen in the northwestern province of Gansu are not being allowed to leave, and police at roadblocks on the perimeter of the city are telling motorists to find alternative routes, state broadcaster China Central Television (CCTV) said. The 38-year-old victim died last Wednesday, the report said, and had been in contact with a dead marmot, a small furry animal which lives on grasslands and is related to the squirrel. "The city has enough rice, flour and oil to supply all its residents for up to one month," the report added. "Local residents and those in quarantine are all in stable condition."
As per CDC and experts in the field, this is a treatable disease if the patient or victim is brought to the right treatment facility in the earlier stages of infection. Hope some Chinese experts in the field of infectious disease inform the authorities about this treatments.
On a second thought, I am inclined to think the China is taking every precaution they can because of their past history of plague that devastated the nations.
Note: This Editorial is not to blame China or say insensitive thing about the nation or its actions, it is finally left to them to deal with the situation as it is appropriate, but a thorough scientific approach is a must.
Chinese Officials Seal Off 'Plague' City, Puzzling US Experts
by Rachael Rettner, LiveScience Staff Writer | July 22, 2014 06:20pm ET
Friday, May 30, 2014
EEG technique and Treatment of Rolandic Epilepsy treatment?.
What was their research model and study is about:Looking at the EEG patterns periodically at certain time difference, could be week or month in between, Yamanashi and his colleague found that there is a repetitive high frequency EEG waveform abnormality that can be used to strategies for treatment?. Although, it is a brief study on small number of children's, EEG recordings and the abnormal waveform morphology is one of the or the only way to ascertain what to do with such epileptic patient, actually, while referring to the recent reviews in this field, I found this compelling review article by Dr.Markand, MD (see at the bottom after the Yamanashi's work).
A total of ten children between the ages of three and ten with recurrent seizures and 12 patients aged between four and seven years who experienced isolated seizures were enrolled in the study, with seizure recurrence and prolonged high-frequency EEG paroxysm data being correlated by the scientists.
Repeated EEG recordings were taken every three months, with clinical and EEG follow-up performed for four or more years. It was discovered that seizure recurrence and extended periods of high-frequency paroxysmal EEG abnormalities for more than 6 months after onset were significantly linked.
New study shows how EEG can aid rolandic epilepsy treatment
This form of epilepsy is generally associated with favourable outcomes, with a moderate proportion of cases characterised by isolated seizure events, meaning continuous treatment need only be considered only for those affected by frequent seizures.
As such, the new research from the University of Yamanashi aimed to identify EEG criteria related to seizure recurrence in rolandic epilepsy, in order to help guide treatment strategies for those in this patient group.
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The review article that I mentioned above:
a good read to get the background idea of how the neurophysiologist, neurologist or clinicians can discern the EEG patterns:
Pearls, Perils, and Pitfalls In the Use of the Electroencephalogram
Thursday, January 16, 2014
Epilepsy: Drug Resistent Focal Epilepsy & Surgical Resection treatments, two Epilepsia Reports
The following two new research reports published in Epilepsia journal [quoted Epilepsy current]might be of interest to those Epilepsy doctors and professionals, ofcourse to Neurophysiologists and long term intraoperative monitoring field.
Fig from-Link: Human Epilepsy Patterns, focal epilepsy,
Quoted: Current Literature In Clinical Science
Are HFOs Still UFOs? The Known and Unknown About High Frequency Oscillations in Epilepsy Surgery
High-Frequency Oscillations, Extent of Surgical Resection, and Surgical Outcome in Drug-Resistant Focal Epilepsy.
Haegelen C, Perucca P, Chatillon CE, Andrade-Valenca L, Zelmann R, Jacobs J, Collins DL, Dubeau F, Olivier A, Gotman J.Epilepsia 2013;54:848–857.
Read the full abstract at: http://www.aesnet.org/files/dmfile/epcu_13.6_273_ClinicalCommentary_Jobst.pdf#!PURPOSE: Removal of areas generating high-frequency oscillations (HFOs) recorded from the intracerebral electroencephalography
(iEEG) of patients with medically intractable epilepsy has been found to be correlated with improved surgical outcome. However, whether differences exist according to the type of epilepsy is largely unknown. We performed a comparative assessment of the impact of removing HFO-generating tissue on surgical outcome between temporal lobe epilepsy (TLE) and extratemporal lobe epilepsy (ETLE). We also assessed the relationship between the extent of surgical resectionand surgical outcome.
And the Full article at Epilesia journal.
Ripple Classification Helps to Localize the Seizure-Onset Zone in Neocortical Epilepsy.
Wang S, Wang IZ, Bulacio JC, Mosher JC, Gonzalez-Martinez J, Alexopoulos AV, Najm IM, So NK.Epilepsia 2013;54:370–376.
For full abstract and article, refer as the previous.PURPOSE: Fast ripples are reported to be highly localizing to the epileptogenic or seizure-onset zone (SOZ) but may not be readily found in neocortical epilepsy, whereas ripples are insufficiently localizing. Herein we classified interictal neocortical ripples by associated characteristics to identify a subtype that may help to localize the SOZ in neocortical epilepsy. We hypothesize that ripples associated with an interictal epileptiform discharge (IED) are more pathologic,since the IED is not a normal physiologic event.
Sunday, October 27, 2013
The Lancet Paper on "Spinal Cord Damage" -some improvement in Movements of Paralyzed Patients
The Lancet Quote "An individual three years post C7-T1 subluxation presented with a complete loss of clinically detectable voluntary motor function and partial preservation of sensation below the T1 cord segment" end of Quote.
In this interesting Lancet paper on neuronal recovery/functional recovery, the authors claims they have noticed significant improvement of Paralyzed patients after implant and electrical stimulation. This new positive results was not achieved by the same group in their own earlier clinical studies, authors say "we have not seen such a result in their earlier research studies".
-------------------------------------------------------------------------------------------------------Spinal cord stimulation studies been done both in lab rats as well as paralyzed patients. This is the latest report on paralyzed patients responding to stimulation with visible movements, it is interesting but we have long way to go to have a wholesome or meaningful treatment of spinal cord damages, it all comes to the extent of damage, and severity of neural paths that are severed by accidents......if the integrity of both afferent and efferent pathways are preserved with mild or minor damages, the recovery can be significant, in cases were more than 50% percent damages or even more severe, that determines the possibility of any recovery. In either case, it is good to read some results. And, when it is published in The Lancet, got to be little credible to listen to the news?..
Effect of Epidural stimulation of the lumbosacral spinal cord on voluntary movement, standing, and assisted stepping after motor complete paraplegia: a case study
Findings
Epidural stimulation enabled the human lumbosacral spinal circuitry to dynamically elicit full weight-bearing standing with assistance provided only for balance for 4·25 minutes in a subject with a clinically motor complete SCI. This occurred when using stimulation at parameters optimized for standing while providing bilateral load-bearing proprioceptive input. Locomotor-like patterns were also observed when stimulation parameters were optimized for stepping. In addition, seven months after implantation, the subject recovered supraspinal control of certain leg movements, but only during epidural stimulation.
Friday, August 9, 2013
Orthopedic Surgeon Spyros Pranos Medical Fraud, 250 Law suits?. a Doctor who Faked and Botched Surgery, what an Evil?
ABC News:
Judgment Day for Surgeon Who Admitted to Fake Surgeries
Orthopedic surgeon Dr.Pranos seems to have had detailed OP notes about treatments to his patients but that never took place?, hmmm....it seems he scheduled as large as 22 surgeries in a single day?, now he is under scrutiny and more than 250 law suits been filed.
Wednesday, June 26, 2013
Nerve Conduction Tests (NCV) in Guillian- Barre Syndrome, what is new?.
Journal Article in Press
Two sets of nerve conduction studies may suffice in reaching a reliable electrodiagnosis in Guillain–Barré syndrome
Nortina Shahrizaila et al..► The existing electrodiagnostic criteria in Guillain–Barré syndrome are unreliable when applied at the initial stages of disease onset. ► Nerve conduction studies performed at two time courses, within 2weeks and 3–8weeks, may better reflect the final electrodiagnosis of Guillain–Barré syndrome. ► The pattern of recovery in Guillain–Barré syndrome is heterogeneous and validation of the current Erasmus Guillain–Barré syndrome outcome score in different patient populations is required.
Sunday, June 23, 2013
No more LinkedIn, No Facebook or other social sites, Beware their Breach is a yet another fraud and drama to sell you!?
I have been monitoring all these so called social and professional networking websites such as LinkedIn, Facebook, google and others. I am sure you all noticed the number of such websites reporting breach and leak of members details or hacking of their sites and it continues without any end to this menace.These companies constantly sell and buy contacts, all the so called breach is not really a breach, or hacking or cyber security issue starts and end with them, they use these to con, sell things, create fake news for promotional purposes etc, you know what that means?:
I realized, our personal information and connections are at serious risk in these bottom feeding companies hands, so as of today, I will be terminating my LinkedIn, two days ago, I have seen lots of contacts been either stolen from other sites and LinkedIn published it on my page. Do you remember on the top right corner a streaming lists will show up everyday, "You may Know these People", have you ever noticed how they get and from where they get those lists, every time you visit or spent few min, you will see several of them are your friends, or colleagues or you know personally?, how do you think LinkedIn get those details, think?.
In my case, I believe either they breached and stolen contacts from my google or outlook contacts or the google would have sold them for a handsome bucks, so do the facebooks leak. Most of this so called breach or leaks are not really leaks but they purposefully create news awareness so that they can get away from any law suits or Feds going after them, because leak or breach is an accident?. wow..
So keep my email contacts, please do not use any of the google, facebook or linked in, use these following secure emails to get in touch with me or network with me. Thanks
Contact: use the contact form to get in touch with me on this topic or any other in this Blog.
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Thursday, June 20, 2013
IONM: Neurological Testing or Neurophysiological Divining? J. G. Salamy, Ph.D.
Dr Joe Salamy writes a thought provoking and insightful Editorial Review about Intraoperative NeuroMonitoring, where do we stand?, what do we have to do to bring in new approach and newer technologies to avoid the IONM field become a stagnant one?..
SummaryDuring the last three decades IONM has followed an objective probability-based clinical model whichfocused attention almost exclusively upon the detection of specific events. IONM practices, however, donot neatly conform to those of conventional clinical testing procedures. It is suggested herein that futureefforts be directed toward developing additional models which elucidate the dynamic and subjectivequalities of IONM and recognize the importance of sequences and their influence upon decision making. Heretofore, the temporal and linguistic aspects of IONM have been largely ignored. It is proposed that weexamine IOMN as an ongoing interactive process, and develop new tools to help accomplish this task.